Table 2 Molecular effects of the ENMs mentioned in the analysed papers (first column), linked to 64 KEs in the AOP-Wiki (AOP-Wiki IDs of the KEs are reported in third column) of which 11 are MIEs (AOP-Wiki IDs of KEs that are MIEs are reported in the second column)
Molecular effects described in paper | AOP-Wiki ID—MIE | AOP-Wiki ID—KE |
|---|---|---|
Activating the NLRP3 inflammasomes | NA | 1895 |
Activation of Nrf2 signaling pathway and increased catalase activity | 478 | 478 |
Activation of post-transcriptional mechanism | NA | NA |
Activation of signaling molecules | NA | NA |
Alter genome methylation | NA | 1773;1778;1622;1827;1620 |
Alveolar Macrophage activation | NA | 1198;1754 |
Apoptosis | NA | 55;1262;1513;1365;1817;1825;1864 |
Apoptotic stimuli | NA | 55;1262;1513;1365;1817;1825;1864 |
Carcinogenicity | NA | 885;1556;1395;1670;1193;1839;1651 |
Cell cycle regulation/progression/control | NA | 854;1555;870;269 |
Cellular sensing of substance or substance induced damage | 1437 | 1437;1459 |
Cellular sensing of the substance-induced Damage resulting in the release of danger signals | 1437 | 1437;1459 |
Condensed cellular size with reduced numbers of protrusions | NA | NA |
Cytoskeleton remodeling | NA | NA |
Decreased inflammatory response | NA | 152 |
Direct stress of epithelium | NA | 1586 |
Disrupt macrophage function | NA | NA |
DNA damage | 1194 | 1461;1551;1194;1766;1635;1669 |
Genotoxicity | 1194 | 1461;1551;1194;1766;1635;1669 |
Histone modifications | 1502 | 1502;1503 |
Increased the number and length of protrusions | NA | NA |
Inducing membranolysis | NA | 169;1498 |
Induction of IL1β and TNFα | NA | 1492;134;1579;1577;1496 |
Induction of IL6 | NA | 87;1493 |
Induction of oxidative stress (CoO > Fe3O4 ≫ SiO2) | 1753;1592;257 | 1364;257;1115;249;1278;1753;1592 |
Inhibition of cellular receptors (dopaminergic, adrenergic, cannabinoid) | NA | 1083 |
Interact with skin proteins | 396 | 396 |
Interaction with lung cells | 1495 | 1495 |
Interference with signaling molecules | NA | NA |
Interruption of calcium sensing receptors | 1529 | 1529 |
Lysosomal injury | NA | 898;831;1540 |
Mitochondrial dysfunction | 177 | 177 |
No effect | NA | NA |
Production of free radicals | 1753;1592;257 | 1364;257;1115;249;1278;1753;1592 |
Proliferation | NA | 854;1555;870;269 |
Promoted activities of SOD and Gpx | NA | NA |
Pulmonary and cardiac effects | NA | NA |
Pulmonary inflammation | NA | 1438 |
Reactions with endogenous molecules | NA | NA |
ROS (increases in the levels of malondialdehyde (MDA)) | 1753;1592;257 | 1364;257;1115;249;1278;1753;1592 |
ROS production | 1753;1592;257 | 1364;257;1115;249;1278;1753;1592 |
ROS production through endoplasmic reticulum stress | 1753;1592;257 | 1364;257;1115;249;1278;1753;1592 |
Surface silanol disorganization | NA | NA |