Table 4 Pocket level evaluation summary table
From: Comparative evaluation of methods for the prediction of protein–ligand binding sites
Method | % Recalltop-N | % Recalltop-N+2 | % Recallmax | % Precision1K | # TP100 FP | % RRO | % RVO |
|---|---|---|---|---|---|---|---|
(d) VN-EGNN | 27.5 (#11) | 40.9 (#12) | 49.3 (#10) | 92.5+ (#1) | 1301+ (#1) | 32.8− (#12) | 27.6− (#11) |
(d) IF-SitePred | 19.8− (#12) | 25.7− (#13) | 52.1 (#6) | 91.0 (#2) | 961 (#3) | 46.5 (#11) | 40.4 (#9) |
(d) GrASP | 48.0 (#2) | 49.9 (#5) | 50.0 (#8) | 92.5+ (#1) | 1017 (#2) | 54.5 (#7) | 59.8 (#6) |
(d) PUResNet | 40.6 (#6) | 41.1 (#11) | 41.1− (#12) | 81.6 (#6) | 534 (#8) | 61.0 (#4) | 63.9 (#4) |
(d) DeepPocketSEG | 35.4 (#10) | 43.8 (#10) | 56.5 (#5) | 82.6 (#4) | 670 (#5) | 57.5 (#5) | 60.3 (#5) |
(d) DeepPocketRESC | 46.6 (#4) | 58.1 (#2) | 89.3 (#2) | 81.7 (#5) | 637 (#6) | 53.1 (#9) | 38.2 (#10) |
(d) P2RankCONS | 48.8+ (#1) | 53.9 (#3) | 57.0 (#4) | 90.7 (#3) | 932 (#4) | 56.4 (#6) | 43.8 (#8) |
(d) P2Rank | 46.7 (#3) | 51.9 (#4) | 57.0 (#3) | 79.2 (#7) | 586 (#7) | 54.4 (#8) | 58.2 (#7) |
(d) fpocketPRANK | 48.8+ (#1) | 60.4+ (#1) | 91.3+ (#1) | 81.7 (#5) | 526 (#9) | 52.6 (#10) | 38.2 (#10) |
(d) fpocket | 38.8 (#8) | 46.5 (#8) | 91.3+ (#1) | 47.3 (#9) | 94 (#11) | 52.6 (#10) | 38.2 (#10) |
(d) PocketFinder+ | 39.2 (#7) | 47.8 (#7) | 50.5 (#7) | 42.0 (#10) | 64 (#12) | 72.3 (#2) | 75.9 (#2) |
(d) Ligsite+ | 41.3 (#5) | 48.4 (#6) | 49.7 (#9) | 52.3 (#8) | 115 (#10) | 77.6+ (#1) | 77.0+ (#1) |
(d) Surfnet+ | 37.7 (#9) | 45.8 (#9) | 48.9 (#11) | 39.5− (#11) | 61− (#13) | 71.7 (#3) | 72.0 (#3) |