Table 1 Performance comparison between MLinvitroTox v1 and MLinvitroTox v2

AR

0.62

0.87

CP

0.66

0.69

GC

0.76

0.89

NR

0.58

0.72

NRC

0.59

0.60

OSR

0.60

0.65

P4

0.70

0.92

XNR

0.51

0.63

Decreased performance

AA

0.69

0.63

ER

0.85

0.80

GTX

0.77

0.71

INF

0.83

0.68

THR

0.78

0.60

Newly introduced targets in v2

AhR

–

0.56

AN

–

0.58

APO

–

0.70

FXR

–

0.62

IM

–

0.64

LXR

–

0.60

MF

–

0.69

NIS

–

0.50

PPARG

–

0.65

PR

–

0.59

PXR

–

0.69

RAR

–

0.64

ROR

–

0.56

RXR

–

0.73

TF

–

0.67

TRH

–

0.59