Fig. 11
Alignments for a query series with terminal morpholine substituent. At the top, morpholine-matching substituents identified in AS alignments based on EFV and CRF similarity are shown, respectively. At the bottom, high-scoring alignments for the query AS are shown based on EFV and CFR similarity, respectively. Alignments scores are reported and the potency of analogues is color-coded according to the pIC50 scale shown at the lower right