HepatoToxicity Portal (HTP): an integrated database of drug-induced hepatotoxicity knowledgebase and graph neural network-based prediction model

Table 1 Collection and characteristics of databases for HTP-KB

Database (Download date)	Affiliations	Hepatotoxicity information accessibility	Toxicity classification	Data format	No. of compound entries	No. of final curated CIDs	Data class
InvitroDB v3.4 (2022.02.04)	EPA (U.S.)	Low	∆	CSV	9329	6466	In vitro
T3DB (2022.07.20)	TMIC (Canada)	Low	O	CSV	3673	955	In vitro In vivo clinical
LiverTox (2022.01.27)	NIH (U.S.)	High	O	PDF	1133	1005	In vitro In vivo clinical
DILIrank (2022.01.27)	FDA (U.S.)	High	O	PDF	1036	669	Clinical
SIDER (2022.02.04)	EMBL (Europe)	Middle	O	PDF	1430	749	Clinical
IRIS (2022.01.28)	EPA (U.S.)	Middle	∆	PDF	666	138	In vivo clinical
CEBS (2022.02.04)	NTP (U.S.)	Low	X	CSV	9209 CASID	230	In vivo
ATSDR (2022.02.03)	CDC (U.S.)	Low	X	PDF	216	145	In vivo clinical
DrugBank v5.1.7 (2020.09.08)	TMIC (Canada)	Low	X	XML	13,580	154	In vitro In vivo clinical

^*Hepatotoxicity accessibility levels (High, Easily accessible to liver-related toxicity results; Middle, Liver-related toxicity data available, yet needs additional filtration; Low, Difficult to extract liver-related results), Toxicity classification levels (O, Classification system is easily interpreted; ∆, Classification exists, yet not systematic; X, There is no classification levels)

ISSN: 1758-2946